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The tetracycline compounds of the invention may be administered alone or in combination with pharmaceutically acceptable carriers or diluents by any of the routes previously mentioned, and the administration may be canied out in single or multiple doses.

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The consortium also recommends considering an alternative drug not metabolized by CYP2C19 in patients who are CYP2C19 ultrarapid metabolizers.

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(J) Doxycycline can increase (Tet-On) or decrease (Tet-Off) gene expression in the nucleus, but its use also impairs mitochondrial translation and function, leading to the generation of a retrograde signal that on its turn affects nuclear gene expression. The language "in combination with" a known composition is intended to include simultaneous administration of the composition of the invention and the known composition, administration of the composition of the invention first, followed by the known composition and administration of the known composition first, followed by the composition of the invention.

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